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- Title
Bronquiolitis obliterante acinar, inducida por sirolimús, en postrasplante de hígado.
- Authors
Guerra-Meza, Carlos Ignacio; Ramírez-Aguilar, Margarita; Ávila-Armendáriz, José Arturo
- Abstract
It has been observed that with the use of sirolimus (rapamycin) as an immunosuppressant in liver transplant there has also been an increase in inexplicable interstitial pneumonitis. Pneumonitis occurs after the drug is withdrawn but it has also manifested after merely reducing the dose of sirolimus. We present the case of a female patient age 56 years, with antecedent of liver transplant, with unproductive cough followed by progressive dyspnea evolving into dyspnea at rest; without fever. In the high-resolution chest tomography we observed extensive infiltrates in the form of ground glass distributed in patches, in both fields, with predominance on the periphery of both lungs and accompanied by thickening of the interlobular septa. A bronchoscopy was performed with transbronchial biopsy and the histopathologic diagnosis was: diffuse damage to the pulmonary acinus with type II hyperplasia of epithelium and formation of fibrous plugs in the alveolar ducts concordant with pneumonia inducing bronchiolitis obliterans.
- Publication
Anales de Radiologia, Mexico, 2013, Vol 12, Issue 2, p127
- ISSN
1665-2118
- Publication type
Article