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- Title
Obesity Is Associated With a Lower Resting Oxygen Saturation in the Ambulatory Elderly: Results From the Cardiovascular Health Study.
- Authors
Kapur, Vishesh K.; Wilsdon, Anthony G.; Au, David; Avdalovic, Mark; Enright, Paul; Fan, Vincent S.; Hansel, Nadia N.; Heckbert, Susan R.; Rui Jiang; Krishnan, Jerry A.; Mukamal, Kenneth; Yende, Sachin; Barr, R. Graham
- Abstract
BACKGROUND: The contribution of obesity to hypoxemia has not been reported in a community- based study. Our hypothesis was that increasing obesity would be independently associated with lower SpO2 in an ambulatory elderly population. METHODS: The Cardiovascular Health Study ascertained resting SpO2in 2,252 subjects over age 64. We used multiple linear regression to estimate the association of body mass index (BMI) with SpO2, and to adjust for potentially confounding factors. Covariates including age, sex, race, smoking, airway obstruction (based on spirometry), self reported diagnosis of emphysema, asthma, heart failure, and left ventricular function (by echocar- diography) were evaluated. RESULTS: Among 2,252 subjects the mean and median SpO2 were 97.6% and 98.0% respectively; 5% of subjects had SpO2values below 95%. BMI was negatively correlated with SpO7 (Spearman R = -0.27, P < .001). The mean difference in SpOi between the lowest and highest BMI categories (< 25 kg/m2 and ≥ 35 kg/m2) was 1.33% (95% CI 0.89-1.78%). In multivariable linear regression analysis, SpO2 was significantly inversely associated with BMI (1.4% per 10 units of BMI, 95% CI 1.2-1.6, for whites/others, and 0.87% per 10 units of BMI, 95% CI 0.47-1.27, for African Americans). CONCLUSIONS: We found a narrow distribution of SpO2) values in a community-based sample of ambulatory elderly. Obesity was a strong independent contributor to a low SpO2, with effects comparable to or greater than other factors clinically associated with lower SpO2
- Subjects
OBESITY complications; ACTIVE oxygen in the body; ANALYSIS of variance; HYPOXEMIA; ANTHROPOMETRY; BLACK people; CARDIAC output; CONFIDENCE intervals; HEART beat; LONGITUDINAL method; OXIMETRY; RACE; RESEARCH funding; PULMONARY function tests; RESPIRATORY obstructions; STATISTICS; T-test (Statistics); WHITE people; PULSE oximeters; DATA analysis; MULTIPLE regression analysis; BODY mass index; DATA analysis software; WAIST circumference; DESCRIPTIVE statistics
- Publication
Respiratory Care, 2013, Vol 58, Issue 5, p831
- ISSN
0020-1324
- Publication type
Article
- DOI
10.4187/respcare.02008