We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Me31B: a key repressor in germline regulation and beyond.
- Authors
Ming Gao
- Abstract
Maternally Expressed at 31B (Me31B), an evolutionarily conserved ATP-dependent RNA helicase, plays an important role in the development of the germline across diverse animal species. Its cellular functionality has been posited as a translational repressor, participating in various RNA metabolism pathways to intricately regulate the spatiotemporal expression of RNAs. Despite its evident significance, the precise role and mechanistic underpinnings of Me31B remain insufficiently understood. This article endeavors to comprehensively review historic and recent research on Me31B, distill the major findings, discern generalizable patterns in Me31B's functions across different research contexts, and provide insights into its fundamental role and mechanism of action. The primary focus of this article centers on elucidating the role of Drosophila Me31B within the germline, while concurrently delving into pertinent research on its orthologs within other species and cellular systems.
- Subjects
GENE expression; GERM cells; RNA helicase; RNA metabolism; ANIMAL species; DNA helicases
- Publication
Bioscience Reports, 2024, Vol 44, Issue 5, p1
- ISSN
0144-8463
- Publication type
Article
- DOI
10.1042/BSR20231769