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- Title
Senseurs moléculaires de la mécanosensation : canaux PIEZOs et potentiels candidats.
- Authors
Delmas, P.; Coste, B.
- Abstract
Mechanotransduction represents the conversion of a mechanical stimulus into an electrical and/or biochemical signal at the cellular level. This phenomenon is of fundamental importance in many processes as diverse as proliferation, differentiation, migration and apoptosis, and in sensory functions, including the sense of touch, proprioception, and nociception. The conversion of the physical stimulus relies on the presence of so-called mechanosensitive ion channels. The identification of PIEZO ion channels and the characterization of their functions in touch and proprioception constitute major advances in our understanding of the molecular processes of mechanotransduction. However, many molecular mechanisms remain to be identified, in particular those involved in mechano-nociception and mechanical pain. This review aims to describe the role of PIEZO channels in somatosensory functions and discusses the latest advances in the identification of new molecular players in mechanotransduction. A better knowledge of these mechanosensory transducers will make it possible to develop new therapeutic strategies in several clinical affections.
- Publication
Douleur et Analgésie, 2022, Vol 35, Issue 4, p213
- ISSN
1011-288X
- Publication type
Article
- DOI
10.3166/dea-2022-0234