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- Title
Paediatric apnoeas are not related to a specific respiratory virus, and parental reports predict hospitalisation.
- Authors
Wishaupt, JO; Berg, EAN; Wijk, T; Ploeg, T; Versteegh, FGA; Hartwig, NG; Wishaupt, J O; van den Berg, Ean; van Wijk, T; van der Ploeg, T; Versteegh, F G A; Hartwig, N G
- Abstract
<bold>Aim: </bold>The aim of this study was to determine the frequency of apnoeas in previously healthy young infants with acute respiratory tract infection (ARI) and correlate their occurrence with isolated micro-organisms, clinical findings, disease severity and outcome.<bold>Methods: </bold>We performed reverse transcriptase real-time polymerase chain reaction (RT-PCR) on the nasal wash specimens of a prospective cohort study of 582 children with ARI. Clinical data on a subgroup of 241 infants under three months of age, with and without apnoeas, were compared.<bold>Results: </bold>Our study found that 19 (7.9%) of the 241 infants under three months old had a history of apnoeas: eight had a respiratory syncytial virus (RSV), five had a different virus than RSV and seven RT-PCR results were negative. Infants with apnoeas were more likely to have cyanosis, had longer hospital stays and required extra oxygen for a longer period. Most patients with parental reported apnoeas also experienced apnoeas during hospitalisation.<bold>Conclusion: </bold>This study observed apnoeas irrespective of the isolated micro-organism, and we hypothesise that they were related to the pathophysiology of the respiratory infection and not to the micro-organism itself. Parental reported apnoeas were a major warning sign and predicted that apnoeas would occur in hospital.
- Subjects
APNEA; INFANT diseases; RESPIRATORY infections in children; SEVERITY of illness index; HOSPITAL care; APNEA treatment; RESPIRATORY infection treatment; VIRAL disease diagnosis; VIRAL disease treatment; COMPARATIVE studies; LONGITUDINAL method; RESEARCH methodology; MEDICAL cooperation; PARENTS; RESEARCH; RESPIRATORY infections; VIRUS diseases; EVALUATION research; TREATMENT effectiveness; CASE-control method; ACUTE diseases; ODDS ratio; DISEASE complications; DIAGNOSIS
- Publication
Acta Paediatrica, 2016, Vol 105, Issue 5, p542
- ISSN
0803-5253
- Publication type
journal article
- DOI
10.1111/apa.13375