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- Title
Control of capillary formation by membrane-anchored extracellular inhibitor of phospholipase A<sub>2</sub>
- Authors
Chen, W.M.; Soria, J.; Soria, C.; Krimsky, M.; Yedgar, S.
- Abstract
Secretory phospholipase A2 (sPLA2) has been reported to be involved in cell proliferation in general and in endothelial cell migration, processes required for capillary formation. Subsequently, we examined the potential control of angiogenesis by sPLA2 inhibition, using a cell-impermeable sPLA2 inhibitor composed of N-derivatized phosphatidyl-ethanolamine linked to hyaluronic acid. This inhibitor effectively inhibits the proliferation and migration of human bone marrow endothelial cells in a dose-dependent manner, and suppresses capillary formation induced by growth factors involved in vascularization of tumors and of atherosclerotic plaques. It is proposed that sPLA2 inhibition introduces a novel approach in the control of cancer development and atherosclerosis.
- Subjects
CELL proliferation; ARACHIDONIC acid; FIBROBLAST growth factors; CYCLOOXYGENASES
- Publication
FEBS Letters, 2002, Vol 522, Issue 1-3, p113
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/S0014-5793(02)02907-1