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- Title
Development and Validation of Spectrophotometric Method for Simultaneous Estimation of Perindopril and Indapamide in Combined Dosage Form by Simultaneous Equation Method.
- Authors
Modi, Darshana K.; Patel, Chhagan N.
- Abstract
A new sensitive, simple, rapid and precise spectrophotometric method has been developed for simultaneous estimation of perindopril and indapamide in pharmaceutical dosage form. This method was based on UV-spectrophotometric determination of two drugs, using simultaneous equation method. It involves measurement of absorbances at two wavelengths 210.4nm (λmax of perindopril) and 241.2nm (λmax of indapamide) in methanol. The linearity was observed in the concentration range of 24 - 56 µg mL-1 for perindopril and 7.5 - 17.5 µg mL-1 for indapamide. The accuracy and precision of the method was determined and validated stastically. The method showed good reproducibility and recovery with % RSD less than 2. Method was found to be rapid, specific, precise and accurate, can be successfully applied for the routine analysis of perindopril and indapamide in bulk, and combined dosage form without any interference by the excipients. The method was validated according to ICH guidelines.
- Subjects
SPECTROPHOTOMETRY; INDAPAMIDE; INDOLE; DOSAGE forms of drugs; SIMULTANEOUS equations; ULTRAVIOLET spectroscopy; THERAPEUTICS
- Publication
Eurasian Journal of Analytical Chemistry, 2011, Vol 6, Issue 1, p46
- ISSN
1306-3057
- Publication type
Article