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- Title
Emerging roles of lysine methylation on non-histone proteins.
- Authors
Zhang, Xi; Huang, Yaling; Shi, Xiaobing
- Abstract
Lysine methylation is a common posttranslational modification (PTM) of histones that is important for the epigenetic regulation of transcription and chromatin in eukaryotes. Increasing evidence demonstrates that in addition to histones, lysine methylation also occurs on various non-histone proteins, especially transcription- and chromatin-regulating proteins. In this review, we will briefly describe the histone lysine methyltransferases (KMTs) that have a broad spectrum of non-histone substrates. We will use p53 and nuclear receptors, especially estrogen receptor alpha, as examples to discuss the dynamic nature of non-histone protein lysine methylation, the writers, erasers, and readers of these modifications, and the crosstalk between lysine methylation and other PTMs in regulating the functions of the modified proteins. Understanding the roles of lysine methylation in normal cells and during development will shed light on the complex biology of diseases associated with the dysregulation of lysine methylation on both histones and non-histone proteins.
- Subjects
LYSINE; NONHISTONE chromosomal proteins; METHYLATION; POST-translational modification; HISTONE genetics; METHYLTRANSFERASES; TRANSCRIPTION factors
- Publication
Cellular & Molecular Life Sciences, 2015, Vol 72, Issue 22, p4257
- ISSN
1420-682X
- Publication type
Article
- DOI
10.1007/s00018-015-2001-4