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- Title
SARS-CoV-2: Advances in Serological Methods and the Understanding of Antibody Escape.
- Authors
Focosi, Daniele; Maggi, Fabrizio
- Abstract
They derived both anti-receptor binding domain (RBD) and anti-N-terminal domain (NTD) mAbs from immunized mice and intriguingly showed how mutations within the RBD can also affect the efficacy of NTD-targeted mAbs. In particular, they found that despite lower cumulative anti-Spike antibody levels, the neutralization capability of sera from vaccine breakthrough infections against BA.1 was higher than that of sera from unvaccinated convalescents. In this Special Issue, many original contributions concerning serological methods for SARS-CoV-2 were collected, some of them with implications about therapeutics.
- Subjects
SARS-CoV-2; MONOCLONAL antibodies; BREAKTHROUGH infections; CONVALESCENT plasma; IMMUNOGLOBULINS
- Publication
International Journal of Molecular Sciences, 2023, Vol 24, Issue 3, p2488
- ISSN
1661-6596
- Publication type
Editorial
- DOI
10.3390/ijms24032488