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- Title
The Multiple Functions of Insulin Put into Perspective: From Growth to Metabolism, and from Well-Being to Disease.
- Authors
Street, Maria Elisabeth; Moghetti, Paolo; Chiarelli, Francesco
- Abstract
Insulin receptor signaling shows significant cross-talks with the IGF-1 receptor type 1, and with FSH and LH signaling, acting as a co-gonadotropin in granulosa and theca cells. It is generally recognized that in most phases of life, insulin resistance in PCOS is associated with an increased risk of developing type 2 diabetes and, possibly, with an increased risk of cardiovascular disease [[11]]. Insulin has pleiotropic effects, and is of importance both as a key regulator of glucose metabolism and as a growth factor.
- Subjects
GESTATIONAL diabetes; INSULIN; GHRELIN receptors; SOMATOMEDIN; INSULIN receptors; METABOLISM; HOMEOSTASIS; WELL-being
- Publication
International Journal of Molecular Sciences, 2023, Vol 24, Issue 1, p200
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms24010200