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- Title
Phytochemicals in Malignant Pleural Mesothelioma Treatment—Review on the Current Trends of Therapies.
- Authors
Chmielewska-Kassassir, Malgorzata; Wozniak, Lucyna A.
- Abstract
Malignant pleural mesothelioma (MPM) is a rare but highly aggressive tumor of pleura arising in response to asbestos fibers exposure. MPM is frequently diagnosed in the advanced stage of the disease and causes poor prognostic outcomes. From the clinical perspective, MPM is resistant to conventional treatment, thus challenging the therapeutic options. There is still demand for improvement and sensitization of MPM cells to therapy in light of intensive clinical studies on chemotherapeutic drugs, including immuno-modulatory and targeted therapies. One way is looking for natural sources, whole plants, and extracts whose ingredients, especially polyphenols, have potential anticancer properties. This comprehensive review summarizes the current studies on natural compounds and plant extracts in developing new treatment strategies for MPM.
- Subjects
MESOTHELIOMA; ASBESTOS; DIAGNOSIS; PHYTOCHEMICALS; PLANT extracts; PHOTOTHERAPY; CELLULAR therapy
- Publication
International Journal of Molecular Sciences, 2021, Vol 22, Issue 15, p8279
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms22158279