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- Title
MYC-Induced Replicative Stress: A Double-Edged Sword for Cancer Development and Treatment.
- Authors
Curti, Laura; Campaner, Stefano
- Abstract
MYC is a transcription factor that controls the expression of a large fraction of cellular genes linked to cell cycle progression, metabolism and differentiation. MYC deregulation in tumors leads to its pervasive genome-wide binding of both promoters and distal regulatory regions, associated with selective transcriptional control of a large fraction of cellular genes. This pairs with alterations of cell cycle control which drive anticipated S-phase entry and reshape the DNA-replication landscape. Under these circumstances, the fine tuning of DNA replication and transcription becomes critical and may pose an intrinsic liability in MYC-overexpressing cancer cells. Here, we will review the current understanding of how MYC controls DNA and RNA synthesis, discuss evidence of replicative and transcriptional stress induced by MYC and summarize preclinical data supporting the therapeutic potential of triggering replicative stress in MYC-driven tumors.
- Subjects
MYC oncogenes; DNA replication; DNA synthesis; CANCER treatment; RNA synthesis; CELL cycle
- Publication
International Journal of Molecular Sciences, 2021, Vol 22, Issue 12, p6168
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms22126168