We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Progress of Induced Pluripotent Stem Cell Technologies to Understand Genetic Epilepsy.
- Authors
Sterlini, Bruno; Fruscione, Floriana; Baldassari, Simona; Benfenati, Fabio; Zara, Federico; Corradi, Anna
- Abstract
The study of the pathomechanisms by which gene mutations lead to neurological diseases has benefit from several cellular and animal models. Recently, induced Pluripotent Stem Cell (iPSC) technologies have made possible the access to human neurons to study nervous system disease-related mechanisms, and are at the forefront of the research into neurological diseases. In this review, we will focalize upon genetic epilepsy, and summarize the most recent studies in which iPSC-based technologies were used to gain insight on the molecular bases of epilepsies. Moreover, we discuss the latest advancements in epilepsy cell modeling. At the two dimensional (2D) level, single-cell models of iPSC-derived neurons lead to a mature neuronal phenotype, and now allow a reliable investigation of synaptic transmission and plasticity. In addition, functional characterization of cerebral organoids enlightens neuronal network dynamics in a three-dimensional (3D) structure. Finally, we discuss the use of iPSCs as the cutting-edge technology for cell therapy in epilepsy.
- Subjects
INDUCED pluripotent stem cells; PLURIPOTENT stem cells; EPILEPSY; NERVOUS system; VAGUS nerve; NEURAL transmission; NEUROLOGICAL disorders
- Publication
International Journal of Molecular Sciences, 2020, Vol 21, Issue 2, p1
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms21020482