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- Title
The EGFR-ERK/JNK-CCL20 Pathway in Scratched Keratinocytes May Underpin Koebnerization in Psoriasis Patients.
- Authors
Kazuhisa Furue; Takamichi Ito; Yuka Tanaka; Akiko Hashimoto-Hachiya; Masaki Takemura; Maho Murata; Makiko Kido-Nakahara; Gaku Tsuji; Takeshi Nakahara; Masutaka Furue
- Abstract
Epidermal keratinocytes represent a rich source of C-C motif chemokine 20 (CCL20) and recruit CCR6+ interleukin (IL)-17A–producing T cells that are known to be pathogenic for psoriasis. A previous study revealed that scratch injury on keratinocytes upregulates CCL20 production, which is implicated in the Koebner phenomenon characteristically seen in psoriasis patients. However, the molecular mechanisms leading to scratch-induced CCL20 production remain elusive. In this study, we demonstrate that scratch injury upregulates the phosphorylation of epidermal growth factor receptor (EGFR) and that the specific EGFR inhibitor PD153035 attenuates scratch-induced CCL20 upregulation in an extracellular signal-related kinase (ERK)-dependent, and to a lesser extent, a c-Jun N-terminal kinase (JNK)-dependent but p38 mitogen-activated protein kinase (MAPK)–independent manner. Immunoreactive CCL20 was visualized in the keratinocytes that lined the scratched wound. IL-17A also induced the phosphorylation of EGFR and further augmented scratch-induced CCL20 upregulation. The EGFR-ERK/JNK-CCL20 pathway in scratched keratinocytes may explain why Koebnerization is frequently seen in psoriasis patients.
- Subjects
KERATINOCYTES; EPIDERMAL growth factor receptors; MITOGEN-activated protein kinases; PSORIASIS
- Publication
International Journal of Molecular Sciences, 2020, Vol 21, Issue 2, p1
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms21020434