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- Title
Yacon (Smallanthus sonchifolius) Leaf Extract Attenuates Hyperglycemia and Skeletal Muscle Oxidative Stress and Inflammation in Diabetic Rats.
- Authors
Santos, Klinsmann Carolo dos; Bueno, Bianca Guerra; Pereira, Luana Ferreira; Francisqueti, Fabiane Valentini; Braz, Mariana Gobbo; Bincoleto, Lahis Fernandes; Silva, Lilian Xavier da; Ferreira, Ana Lúcia A.; Nakamune, Ana Cláudia de Melo Stevanato; Chen, C.-Y. Oliver; Blumberg, Jeffrey B.; Corrêa, Camila Renata
- Abstract
The effects of hydroethanolic extract of Yacon leaves (HEYL) on antioxidant, glycemic, and inflammatory biomarkers were tested in diabetic rats. Outcome parameters included glucose, insulin, interleukin-6 (IL-6), and hydrophilic antioxidant capacity (HAC) in serum and IL-6, HAC, malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) in soleus. The rats (10/group) were divided as follows: C, controls; C + Y, HEYL treated; DM, diabetic controls; and DM + Y, diabetic rats treated with HEYL. Diabetes mellitus was induced by administration of streptozotocin. C + Y and DM + Y groups received 100 mg/kg HEYL daily via gavage for 30 d. Hyperglycemia was improved in the DM + Y versus DM group. Insulin was reduced in DM versus C group. DM rats had higher IL-6 and MDA and lower HAC in the soleus muscle. HEYL treatment decreased IL-6 and MDA and increased HAC in DM rats. DM + Y rats had the highest CAT activity versus the other groups; GPx was higher in C + Y and DM + Y versus their respective controls. The apparent benefit of HEYL may be mediated via improving glucoregulation and ameliorating oxidative stress and inflammation, particularly in diabetic rats.
- Subjects
ANIMAL experimentation; ANTIOXIDANTS; BIOMARKERS; HYPERGLYCEMIA; INFLAMMATION; INSULIN; INTERLEUKINS; LEAVES; OXIDOREDUCTASES; RATS; SUPEROXIDE dismutase; MALONDIALDEHYDE; PLANT extracts; OXIDATIVE stress; CALF muscles; SKELETAL muscle; GLYCEMIC control
- Publication
Evidence-based Complementary & Alternative Medicine (eCAM), 2017, Vol 2017, p1
- ISSN
1741-427X
- Publication type
Article
- DOI
10.1155/2017/6418048