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- Title
(Z)-4-(Carbomethoxymethylene)-2-(4-fluorophenyl)-4H-benzo[d][1,3]oxazine.
- Authors
Pancrazzi, Francesco; Motti, Elena; Costa, Mirco; Mancuso, Raffaella; Gabriele, Bartolo; Della Ca', Nicola
- Abstract
The title compound, (Z)-4-(carbomethoxymethylene)-2-(4-fluorophenyl)-4H-benzo[d][1,3] oxazine, was synthesized in 68% isolated yield by palladium-catalyzed oxidative cyclization-methoxycarbonylation of 4-fluoro-N-(2-((trimethylsilyl)ethynyl)phenyl)benzamide. This new heterocyclic derivative was fully characterized by IR, 1H-NMR, 13C-NMR spectroscopies, MS spectrometry, and elemental analysis. The Z configuration around the double bond was unequivocally established by 2D NOESY experiments.
- Subjects
HETEROCYCLIC compounds synthesis; CARBONYLATION; CHEMICAL reactions; HYDROFORMYLATION; BENZOXAZINES
- Publication
Molbank, 2017, Vol 2017, Issue 1, pm927
- ISSN
1422-8599
- Publication type
Article
- DOI
10.3390/M927