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- Title
Variability of Response Time as a Predictor of Methylphenidate Treatment Response in Korean Children with Attention Deficit Hyperactivity Disorder.
- Authors
Seung-Hye Lee; Dong-Ho Song; Bung-Nyun Kim; Yoo Sook Joung; Eun Hye Ha; Keun-Ah Cheon; Yee-Jin Shin; Hee Jeong Yoo; Dong-Won Shin
- Abstract
Purpose: Methylphenidate (MPH) is an effective medication for the treatment of attention deficit hyperactivity disorder (ADHD). However, about 30% of patients do not respond to or are unable to tolerate MPH. Based on previous findings, we hypothesized that great variability in response time (RT) among Korean children with ADHD on a computerized continuous performance attention test would be related to poor MPH treatment response. Materials and Methods: Children (ages 6-18 years) with ADHD were recruited for a prospective 12-week, openlabeled, multicenter study to examine optimal dosage of OROS methylphenidate. Of the 144 subjects selected, 28 dropped out due to adverse events, medication noncompliance, or follow-up loss, and an additional 26 subjects with comorbid disorders were excluded from statistical analyses. We defined 'responders' as subjects who received a score of less than 18 on the attention deficit hyperactivity disorder rating scale (ARS; Korean version, K-ARS) and a score of 1 or 2 on the Clinical Global Impression-Improvement scale (CGI-I). RT variability was assessed with the ADHD diagnostic system (ADS). Results: Fifty-nine (67%) subjects responded to MPH treatment. The nonresponders showed greater RT variability at baseline (Mann Whitney U = 577.0, p < 0.01). Baseline RT variability was a significant predictor of MPH response (Nagelkerke R2 = 0.136, p < 0.01). It predicted 94.9% of responder, 17.2% of non-responder and 69.3% of overall group. Conclusion: High RT variability may predict poor response to MPH treatment in children with ADHD.
- Subjects
METHYLPHENIDATE; TREATMENT of attention-deficit hyperactivity disorder; TREATMENT of behavior disorders in children; CHILDREN with attention-deficit hyperactivity disorder; EXCEPTIONAL children; DRUG efficacy; REACTION time
- Publication
Yonsei Medical Journal, 2009, Vol 50, Issue 5, p650
- ISSN
0513-5796
- Publication type
Article
- DOI
10.3349/ymj.2009.50.5.650