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- Title
Transcriptome research on spermatogenic molecular drive in mammals.
- Authors
Zi-Jue Zhu; Shi Yang; Zheng Li
- Abstract
It is known that spermatogenic disorders are associated with genetic deficiency, although the primary mechanism is still unclear. It is difficult to demonstrate the molecular events occurring in testis, which contains germ cells at different developmental stages. However, transcriptomic methods can help us reveal the molecular drive of male gamete generation. Many transcriptomic studies have been performed on rodents by utilizing the timing of the first wave of spermatogenesis, which is not a suitable strategy for research in fertile men. With the development of separation methods for male germ cells, transcriptome research on the molecular drive of spermatogenesis in fertile men has seen great progress, and the results could be ultimately applied to improve the diagnosis and treatment for male infertility.
- Publication
Asian Journal of Andrology, 2015, Vol 17, Issue 6, p961
- ISSN
1008-682X
- Publication type
Article
- DOI
10.4103/1008-682X.159721