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- Title
Endothelium-specific gene and stem cell-based therapy for erectile dysfunction.
- Authors
Strong, Travis D.; Gebska, Milena A.; Burnett, Arthur L.; Champion, Hunter C.; Bivalacqua, Trinity J.
- Abstract
Erectile dysfunction (ED) commonly results from endothelial dysfunction of the systemic vasculature. Although phosphodiesterase type 5 (PDE-5) inhibitors are effective at treating most cases of ED, they must be taken routinely and are ineffectual for a meaningful number of men. In recent years gene and stem cell-based therapies targeted at the penile endothelium have been gaining momentum in preclinical studies. These early studies reveal that gene and stem cell-based therapies may be both enduring and efficacious, and may eventually lead to a cure for ED. The following review will highlight our current understanding of endothelial-specific gene and stem cell-based therapies performed to date in a number of experimental animal models.
- Publication
Asian Journal of Andrology, 2008, Vol 10, Issue 1, p14
- ISSN
1008-682X
- Publication type
Article
- DOI
10.1111/j.1745-7262.2008.00362.x