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- Title
Ribozyme catalysis: not different, just worse.
- Authors
Doudna, Jennifer A.; Lorsch, Jon R.
- Abstract
Evolution has resoundingly favored protein enzymes over RNA-based catalysts, yet ribozymes occupy important niches in modern cell biology that include the starring role in catalysis of protein synthesis on the ribosome. Recent results from structural and biochemical studies show that natural ribozymes use an impressive range of catalytic mechanisms, beyond metalloenzyme chemistry and analogous to more chemically diverse protein enzymes. These findings make it increasingly possible to compare details of RNA- and protein-based catalysis.
- Subjects
CATALYTIC RNA; NUCLEASES; RNA; CYTOLOGY; PROTEIN synthesis; BIOLOGY
- Publication
Nature Structural & Molecular Biology, 2005, Vol 12, Issue 5, p395
- ISSN
1545-9993
- Publication type
Article
- DOI
10.1038/nsmb932