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- Title
Navigating the ClpB channel to solution.
- Authors
Shorter, James; Lindquist, Susan
- Abstract
This article discusses that simple clearance of aggregated protein is necessary for cell stress tolerance. Excessive protein misfolding and aggregation can be fatal, and contribute to devastating disorders as diverse as sickle cell anemia, type II diabetes and new variant Creutzfeldt-Jakob disease. Thus, sophisticated molecular chaperone, osmolyte and proteolytic systems have evolved to minimize protein misfolding and eliminate misfolded conformers when they appear. Environmental stress, such as high temperatures, can overwhelm these systems and induce potentially catastrophic protein aggregation.
- Subjects
PROTEINS; CREUTZFELDT-Jakob disease; PRESENILE dementia; MOLECULAR chaperones; SICKLE cell anemia; BLOOD diseases
- Publication
Nature Structural & Molecular Biology, 2005, Vol 12, Issue 1, p4
- ISSN
1545-9993
- Publication type
Article
- DOI
10.1038/nsmb0105-4