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- Title
Enzymatic N-Glycosylation of Diverse Arylamine Aglycones by a Promiscuous Glycosyltransferase from Carthamus tinctorius.
- Authors
Xie, Kebo; Chen, Ridao; Chen, Dawei; Li, Jianhua; Wang, Ruishan; Yang, Lin; Dai, Jungui
- Abstract
A new glycosyltransferase (UGT71E5) from Carthamus tinctorius exhibited a robust promiscuity towards 30 structurally diverse drug-like aromatic amine scaffolds, making it the first reported glycosyltransferase capable of catalyzing N-glycosylation with multiple diverse nitrogen-heterocyclic aromatic compounds. The catalytic promiscuity and reversibility of UGT71E5 was exploited to generate the rare N-glycoside from the abundant O-glycoside with high efficiency. These findings demonstrate the significant potential of UGT71E5 in the enzymatic synthesis of diverse bioactive N-glycosides.
- Subjects
GLYCOSYLTRANSFERASES; SAFFLOWER; CATALYSIS; BIOACTIVE compounds; AROMATIC compounds
- Publication
Advanced Synthesis & Catalysis, 2017, Vol 359, Issue 4, p603
- ISSN
1615-4150
- Publication type
Article
- DOI
10.1002/adsc.201601128