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- Title
Age-related effects of DHEA on peripheral markers of oxidative stress.
- Authors
Jacob, Maria Helena Vianna Metello; da R. Janner, Daiane; Jahn, Matheus Parmegiani; Kucharski, Luiz Carlos; Belló-Klein, Adriane; Ribeiro, Maria Flavia Marques
- Abstract
Ageing is an inevitable biological process characterized by a general decline in various physiological functions. DHEA and DHEAS levels are maximal between the second and third life decades, then start to decline 2% per year, leaving a residual of 10-20% of the peak production by the eighth decade. Erythrocytes are exposed to frequent oxidative stress due to the oxygen radicals continuously generated by haemoglobin auto-oxidation. We investigated DHEA chronic (10 mg/kg, subcutaneously, for 5 weeks) effects over oxidative stress markers in erythrocytes of male Wistar rats of 3, 13 and 18 month-old. In the 13 month-old group, we found increased lipid peroxidation (LPO), superoxide dismutase (SOD), glutathione-S-transferase and catalase activities when compared to the other age groups. DHEA produced a marked increase in LPO of 13 month-old group when compared to its control. DHEA exerted this pro-oxidant effects in all ages studied, especially in age 13 month-old. It seems that at 13 month-old there would be an important depletion of some specific anti-oxidant in order to determine such susceptibility to DHEA effects. Since this approach allows a minimally invasive assessment, it would be useful as a routine method in human clinical studies investigating DHEA effects during the ageing process. Copyright © 2009 John Wiley & Sons, Ltd.
- Publication
Cell Biochemistry & Function, 2010, Vol 28, Issue 1, p52
- ISSN
0263-6484
- Publication type
Article
- DOI
10.1002/cbf.1619