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- Title
Cytotoxic Naphtho- γ-pyrones from the Mangrove Endophytic Fungus Aspergillus tubingensis (GX1-5E).
- Authors
Huang, Hong-Bo; Xiao, Ze-En; Feng, Xiao-Jun; Huang, Cai-Huan; Zhu, Xun; Ju, Jian-Hua; Li, Meng-Feng; Lin, Yong-Cheng; Liu, Lan; She, Zhi-Gang
- Abstract
Four new dimeric naphtho- γ-pyrones, named rubasperone D ( 1), rubasperone E ( 2), rubasperone F ( 3), and its atropisomer rubasperone G ( 4), together with four known monomeric naphtho- γ-pyrones, TMC 256 A1 ( 5), rubrofusarin B ( 6), fonsecin ( 7), and flavasperone ( 8), were isolated from the mangrove endophytic fungus Aspergillus tubingensis (GX1-5E) cultivated in solid rice medium. Their structures were elucidated by spectroscopic methods, including IR, 1D- and 2D-NMR, and MS. In the in vitro cytotoxicity assays, 5 displayed inhibitory activities against tumor cell lines of MCF-7, MDA-MB-435, Hep3B, Huh7, SNB19, and U87 MG with IC50 values between 19.92 and 47.98 μ M. Compounds 1, 6, and 8 also showed mild cytotoxic activity.
- Subjects
ASPERGILLUS; ENDOPHYTIC fungi; CANCER cells; CELL lines; CELL culture
- Publication
Helvetica Chimica Acta, 2011, Vol 94, Issue 9, p1732
- ISSN
0018-019X
- Publication type
Article
- DOI
10.1002/hlca.201100050