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- Title
Structural analysis of unstable norbixin isomers guided by pure shift nuclear magnetic resonance.
- Authors
Bertho, Gildas; Oumezziane, Imed Eddine; Caradeuc, Cédric; Guibout, Louis; Balducci, Christine; Dinan, Laurence; Dilda, Pierre J.; Camelo, Serge; Lafont, René; Giraud, Nicolas
- Abstract
We report the analysis of complex samples obtained during the microwave irradiation/heating of norbixin, which has been identified as a potential therapeutic target for age‐related macular degeneration (AMD). In this context, identifying the different isomers that are obtained during its degradation is of primary importance. However, this characterization is challenging because, on the one hand, some of these isomers are unstable, and on the other hand, the 1H spectra of these isomeric mixtures are poorly resolved. We could successfully apply 1D pure shift experiments to obtain ultrahigh‐resolution 1H nuclear magnetic resonance (NMR) spectra of the norbixin isomer samples and exploit their information content to analyze complementary 2D NMR data and describe accurately their isomeric composition.
- Subjects
NUCLEAR magnetic resonance; CHEMICAL shift (Nuclear magnetic resonance); RETINAL degeneration; ISOMERS; MAGIC angle spinning
- Publication
Magnetic Resonance in Chemistry, 2022, Vol 60, Issue 5, p504
- ISSN
0749-1581
- Publication type
Article
- DOI
10.1002/mrc.5252