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- Title
Antinociceptive and anti-inflammatory properties of α-d-mannan from the yeast Kluyveromyces marxianus: evidence for a role in interleukin-6 inhibition.
- Authors
Calumby, Renata Freitas de A. T.; de Lima, Flávia Oliveira; Valasques Junior, Gildomar Lima; Santos, Jener David Gonçalves; Chaves, Pedro Felipe Pereira; Cordeiro, Lucimara Mach Côrtes; Villarreal, Cristiane Flora; Soares, Milena Botelho Pereira; Boffo, Elisangela Fabiana; de Assis, Sandra Aparecida
- Abstract
The management of inflammatory states typically involves non-steroidal anti-inflammatory drugs (NSAIDs) and opiates. Understanding the mechanisms underlying the processing of nociceptive information from potential alternatives such as some polysaccharides may enable new and meaningful therapeutic approaches. In this study, α-d-mannan isolated from the Kluyveromyces marxianus cell wall produced antinociceptive effects in models of inflammatory pain (formalin and complete Freund’s adjuvant tests). Furthermore, α-d-mannan reduced paw edema and interleukin-6 (IL-6) production after carrageenan-induced inflammation. The polysaccharide α-d-mannan was characterized by gas chromatography–mass spectrometry, methylation analysis, and spectroscopic techniques. Moreover, the Doehlert experimental design was applied to find the optimal conditions for biomass production, with the best conditions being 10.8 g/L and 117 h for the glucose concentration and the fermentation time, respectively. These results indicate that α-d-mannan from K. marxianus exerts anti-inflammatory and antinociceptive effects in mice, possibly via a mechanism dependent on the inhibition of IL-6 production.
- Publication
Archives of Microbiology, 2023, Vol 205, Issue 12, p1
- ISSN
0302-8933
- Publication type
Article
- DOI
10.1007/s00203-023-03718-2