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- Title
Low-Dose Weekly Docetaxel Is as Tolerable as Pemetrexed in Previously Treated Advanced Non-Small-Cell Lung Cancer.
- Authors
Chung, Fu-Tsai; Lee, Kang-Yun; Fang, Yueh-Fu; Shieh, Meng-Heng; Lin, Shu-Min; Yu, Chih-Teng; Lo, Yun-Lun; Lin, Ting-Yu; Kuo, Chih-Hsi; Feng, Po-Hao; Ni, Yung-Lun; Kuo, Han-Pin
- Abstract
Objectives: Docetaxel and pemetrexed have been validated as therapeutics for previously treated advanced non-small-cell lung cancer (NSCLC), but tolerability is a concern for standard treatment with docetaxel administered once every 3 weeks (tri-weekly 75-mg/m2 schedule). We conducted this retrospective study to compare the efficacy and toxicity of weekly low-dose docetaxel versus tri-weekly pemetrexed for previously treated advanced NSCLC. Methods: Consecutive patients who received low-dose single docetaxel (30 mg/m2 on days 1 and 8 every 3 weeks) or pemetrexed (500 mg/m2 every 3 weeks) at a single university-affiliated hospital following failure of previous treatment were retrospectively reviewed. Their outcomes and toxicity profiles were determined. Results: 179 patients were included between 2005 and 2008 (docetaxel, n = 79; pemetrexed, n = 100). Both groups had similar hematologic (16.5 vs. 15.0%; p = 0.84) and non-hematologic (20.3 vs. 24%; p = 0.55) toxicities. After controlling for confounding factors, docetaxel remained superior to pemetrexed for progression-free survival (median 4.0 vs. 2.4 months; hazard ratio 0.64; 95% CI 0.47-0.87; p = 0.005) and overall survival (median 15.0 vs.8.5 months; hazard ratio 0.54; 95% CI 0.38-0.77; p <0.001). Conclusion: Although this study showed that weekly low doses of docetaxel were as tolerable as pemetrexed for previously treated advanced NSCLC, a prospective design is needed to confirm this finding. Copyright © 2011 S. Karger AG, Basel
- Subjects
DOCETAXEL; CANCER treatment; SMALL cell lung cancer; DRUG toxicity; PHARMACODYNAMICS; DRUG dosage; HEALTH outcome assessment; RETROSPECTIVE studies
- Publication
Chemotherapy (0009-3157), 2011, Vol 57, Issue 2, p147
- ISSN
0009-3157
- Publication type
Article
- DOI
10.1159/000321037