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- Title
Molecular approach to the classification of chronic fibrosing lung disease—there and back again.
- Authors
Verleden, Stijn E.; Braubach, Peter; Kuehnel, Mark; Dickgreber, Nicolas; Brouwer, Emily; Tittmann, Pauline; Laenger, Florian; Jonigk, Danny
- Abstract
Chronic diffuse parenchymal lung disease (DPLD) is an umbrella term for a very heterogeneous group of lung diseases. Over the last decades, clinical, radiological and histopathological criteria have been established to define and separate these entities. More recently the clinical utility of this approach has been challenged as a unifying concept of pathophysiological mechanisms and a shared response to therapy across the disease spectrum have been described. In this review, we discuss molecular motifs for subtyping and the prediction of prognosis focusing on genetics and markers found in the blood, lavage and tissue. As a purely molecular classification so far lacks sufficient sensitivity and specificity for subtyping, it is not routinely used and not implemented in international guidelines. However, a better molecular characterization of lung disease with a more precise identification of patients with, for example, a risk for rapid disease progression would facilitate more accurate treatment decisions and hopefully contribute to better patients' outcomes.
- Subjects
LUNG diseases; INTERSTITIAL lung diseases; IDIOPATHIC pulmonary fibrosis; PULMONARY fibrosis; PROGNOSIS
- Publication
Virchows Archiv: European Journal of Pathology, 2021, Vol 478, Issue 1, p89
- ISSN
0945-6317
- Publication type
Article
- DOI
10.1007/s00428-020-02964-9