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- Title
Chronic Generalized Lymphadenopathy in a Child—Progressive Transformation of Germinal Centers (PTGC).
- Authors
Wills, Carson; Mercer, Katherine; Malysz, Jozef; Rivera Galvis, Lidys; Gowda, Chandrika
- Abstract
Background: Enlarged lymph nodes are a common complaint in a Pediatrician's office. Diagnosis of reactive lymphadenopathy secondary to infectious, inflammatory, immune dysregulation calls for clinical investigation, including a thorough history, physical exam, imaging, and less often, a biopsy of the lymph node. Here we discuss a rare presentation of extensive generalized, chronic, waxing, and waning lymphadenopathy diagnosed as Progressive Transformation of Germinal Centers (PTGC) and the course of illness over eight years follow up period. Discussion: Progressive Transformation of Germinal Centers (PTGC) is considered a benign condition, but extensive recurrent generalized lymphadenopathy in a very young child has not been reported before. This case demonstrates the importance of long-term follow-up and tailoring the diagnostic work-up and management based on new signs and symptoms. Here we focus on the clinical considerations and management of complex presentation of a common clinical finding.
- Subjects
LYMPHATIC disease diagnosis; CHRONIC disease diagnosis; PHYSICAL diagnosis; PATIENT aftercare; HOSPITAL emergency services; BIOPSY; AXILLA; WHITE people; SURGICAL excision; LYMPH node surgery; CHILDREN
- Publication
Children, 2022, Vol 9, Issue 2, p214
- ISSN
2227-9067
- Publication type
Article
- DOI
10.3390/children9020214