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- Title
Caution on the Use of <sup>68</sup>Ga-DOTATATE for the Diagnosis of Pheochromocytoma: A Report of 2 Cases.
- Authors
Needleman, Leor; Enamandram, Sheila; Annes, Justin P
- Abstract
Pheochromocytomas are intra-adrenal sympathetic neuroendocrine tumors that arise from chromaffin cells. Paragangliomas similarly arise from chromaffin cells, although at extra-adrenal sites such as sympathetic paraganglia in the abdomen/thorax, or parasympathetic paraganglia in the head/neck. Collectively, pheochromocytomas and paragangliomas are important to diagnose and resect because they may secrete harmful levels of catecholamines, have mass effects, hemorrhage, and/or metastasize. Anatomic imaging of pheochromocytomas is usually completed with computed tomography or magnetic resonance imaging; however, functional imaging may be used to provide additional localization, staging, and/or biologic information. Accordingly, selection of the proper functional imaging modality can be critical to developing the optimal therapeutic strategy. 68Gallium- and 64Copper-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)-octreotate positron emission tomography computed tomography (68Ga- and 64Cu-DOTATATE) are widely used in evaluating pheochromocytomas and paragangliomas, although data regarding the sensitivity for diagnosing pheochromocytoma are limited. We report 2 cases of pheochromocytoma that showed nondiagnostic 68Ga-DOTATATE uptake but were subsequently visualized using alternative functional imaging modalities. Additionally, we provide a review of the literature to highlight the underappreciated limitations of functional adrenal imaging with somatostatin-based compounds.
- Subjects
PARAGANGLIOMA; POSITRON emission tomography computed tomography; PHEOCHROMOCYTOMA; CHROMAFFIN cells; MAGNETIC resonance imaging; LITERATURE reviews
- Publication
JCEM Case Reports, 2023, Vol 1, Issue 6, p1
- ISSN
2755-1520
- Publication type
Article
- DOI
10.1210/jcemcr/luad149