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- Title
Cyclic Combination Chemotherapy for Metastatic Breast Cancer: Comparison of Two CMF Schedules.
- Authors
Biran, S.; Brufman, G.
- Abstract
104 nonrandomized patients suffering from metastatic breast cancer were treated with monthly cycles of cyclophosphamide, methotrexate and 5-fluorouracil (CMF). One group (group A, 44 patients) received low-dose CMF and another one (group B, 60 patients) received standard doses. In both cases, therapy was cycled every 29 days. Group A patients had a response rate of 50.7%, including 5 complete remissions. The median duration of response was 8.2 months. For group B patients, the response rate was of 68.1%, including 10 complete remissions. The median duration of response was 10.6 months. Toxicity was greater in group B patients, the main side effects being nausea, vomiting, leukopenia, thrombocytopenia, alopecia and stomatitis. Copyright © 1981 S. Karger AG, Basel
- Publication
Oncology, 1981, Vol 38, Issue 5, p257
- ISSN
0030-2414
- Publication type
Article
- DOI
10.1159/000225564