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- Title
Triptofan ve Sağlık.
- Authors
ÖZTÜRK, Meryem Elif; YABANCI AYHAN, Nurcan
- Abstract
Tryptophan is an essential aromatic aminoacid. It plays role for the important substances synthesis such as serotonine, melatonine, tryptamine, nicotinic acid. Therefore, it affects some physiological conditions such as weight gain, sleep activity, mood, pain. Daily triptophan requirement is 5 mg per kg body weight. Brain tryptophan uptake and conversion to active metabolites there, related with its amount of intake and presence of other aminoacids especially large neutral amino acids (valine, leucine, isoleucine, phenylalanine, tyrosine) in blood. Acute tryptophan depletion increases energy intake from foods high in sugar in overweight adults, stimulates depressive responses in patients with depression, decreases sleep duration and efficiancy, causes impaired long-term memory functioning and increases migraine symptoms and photophobia in patients who suffer from migraine. Except for sleep problems, there is no drug-like, active effects of tryptophan taken in food for diseases. Neverthless, tryptophan supplement has been used for a long time especially for depression, some cognitive problems, chronic pain and sleep problems. Besides, it is reported that tryptophan supplement decreases energy intake and provides weight loss alone in overweight adults. However, in 1989 since it caused eosinophilia myalgia syndrome and most of people harmed, it was banned by Food and Drug Administration for a while and in 2005, this ban was lifted. Because of using tryptophan two cases having eosinophilia myalgia sendrome and 2 cases having myalgias have been reported since 2005.
- Publication
Journal of Traditional Medical Complementary Therapies, 2020, Vol 3, Issue 3, p406
- ISSN
2630-6425
- Publication type
Article
- DOI
10.5336/jtracom.2020-74288