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- Title
What's taking so long? S-phase entry from quiescence versus proliferation.
- Authors
Coller, Hilary A.
- Abstract
There is a short window in the mammalian cell cycle during which cells can respond to extracellular cues by withdrawing temporarily from the cell cycle. When these cells re-enter the cell cycle, they require several extra hours in the G1 phase before they replicate their DNA compared with their cycling counterparts. More than 20 years after this initial observation, we still do not understand what is taking so long.
- Subjects
CELL cycle; CELL proliferation; MAMMAL cytology; DNA replication; PHOSPHORYLATION; CYCLINS; CELLS
- Publication
Nature Reviews Molecular Cell Biology, 2007, Vol 8, Issue 8, p667
- ISSN
1471-0072
- Publication type
Article
- DOI
10.1038/nrm2223