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- Title
Signalling: Mixed-lineage kinase control of JNK and p38 MAPK pathways.
- Authors
Gallo, Kathleen A.; Johnson, Gary L.
- Abstract
Mixed-lineage kinases (MLKs) are serine/threonine protein kinases that regulate signalling by the c-Jun amino-terminal kinase (JNK) and p38 mitogen-activated-protein kinase (MAPK) pathways. MLKs are represented in the genomes of both Caenorhabditis elegans and Drosophila melanogaster. The Drosophila MLK Slipper regulates JNK to control dorsal closure during embryonic morphogenesis. In mammalian cells, MLKs are implicated in the control of apoptosis and are potential drug targets for many neurodegenerative diseases.
- Subjects
SERINE; AMINOTRANSFERASES; MITOGENS; PROTEIN synthesis; MOLECULAR biology
- Publication
Nature Reviews Molecular Cell Biology, 2002, Vol 3, Issue 9, p663
- ISSN
1471-0072
- Publication type
Article
- DOI
10.1038/nrm906