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- Title
Opinion: What messenger RNA capping tells us about eukaryotic evolution.
- Authors
Shuman, Stewart
- Abstract
The 5′ cap is a unique feature of eukaryotic cellular and viral messenger RNA that is absent from the bacterial and archaeal domains of life. The cap is formed by three enzymatic reactions at the 5′ terminus of nascent mRNAs. Although the capping pathway is conserved in all eukaryotes, the structure and genetic organization of the component enzymes vary between species. These differences provide insights into the evolution of eukaryotes and eukaryotic viruses.
- Subjects
EUKARYOTIC cells; MESSENGER RNA; CELLULAR evolution; BIOLOGICAL evolution; BIOLOGY
- Publication
Nature Reviews Molecular Cell Biology, 2002, Vol 3, Issue 8, p619
- ISSN
1471-0072
- Publication type
Article
- DOI
10.1038/nrm880