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- Title
猪繁殖与呼吸综合征病毒感染Marc-145 细胞的长链非编码RNA 和mRNA 转录组分析.
- Authors
张小霞; 杨艳青; 王秋云; 杜俊阳; 曹瀚文; 梁振普
- Abstract
In order to dig the changes of lncRNA and mRNA expression profiles in host cells after porcine reproductive and respiratory syndrome virus (PRRSV) infection of Marc⁃145 cells, the lncRNA and mRNA of Marc⁃145 infected with PRRSV were sequenced and analyzed by transcriptome. Bioinformatics analysis showed that 39 differentially expressed lncRNAs (DElncRNAs) and 1 320 differentially expressed mRNAs (DEGs) were obtained in Marc⁃145 cells after PRRSV infection.Further enrichment analysis results showed that these DElncRNAs and DEGs were mainly enriched in oxidative phosphorylation signaling pathway.Integration analysis of DElncRNAs and DEGs showed that lncRNA co⁃expressed mRNAs were mainly enriched in MAPK signaling pathway, insulin signaling pathway, neurotrophin signaling pathway, AMPK signaling pathway, HIF⁃1 signaling pathway, protein processing in endoplasmic reticulum and carbon metabolism, which were mainly related to immunity.In conclusion, RRSV infection causes changes in the lncRNA and mRNA expression profiles of Marc⁃145 cells.By bioinformatics analysis, it is speculated that the differential expression products may play an important role in the host’s innate immune response to PRRSV infection.
- Subjects
PORCINE reproductive &; respiratory syndrome; GENE expression; CELLULAR signal transduction; CARBON metabolism; AMP-activated protein kinases
- Publication
Journal of Henan Agricultural Sciences, 2023, Vol 52, Issue 4, p127
- ISSN
1004-3268
- Publication type
Article
- DOI
10.15933/j.cnki.1004⁃3268.2023.04.015