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- Title
Origin, homeostasis and function of Langerhans cells and other langerin-expressing dendritic cells.
- Authors
Merad, Miriam; Ginhoux, Florent; Collin, Matthew
- Abstract
Langerhans cells (LCs) are a specialized subset of dendritic cells (DCs) that populate the epidermal layer of the skin. Langerin is a lectin that serves as a valuable marker for LCs in mice and humans. In recent years, new mouse models have led to the identification of other langerin+ DC subsets that are not present in the epidermis, including a subset of DCs that is found in most non-lymphoid tissues. In this Review we describe new developments in the understanding of the biology of LCs and other langerin+ DCs and discuss the challenges that remain in identifying the role of different DC subsets in tissue immunity.
- Subjects
SKIN; LANGERHANS cells; CELLULAR immunity; LECTINS; PATHOGENIC microorganisms; THERAPEUTICS
- Publication
Nature Reviews Immunology, 2008, Vol 8, Issue 12, p935
- ISSN
1474-1733
- Publication type
Article
- DOI
10.1038/nri2455