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- Title
The discovery of modular binding domains: building blocks of cell signalling.
- Authors
Mayer, Bruce J.
- Abstract
Cell signalling - the ability of a cell to process information from the environment and change its behaviour in response - is a central property of life. Signalling depends on proteins that are assembled from a toolkit of modular domains, each of which confers a specific activity or function. The discovery of modular protein- and lipid-binding domains was a crucial turning point in understanding the logic and evolution of signalling mechanisms.
- Subjects
CELL communication; LIPIDS; CELLULAR control mechanisms; BACTERIAL cell interaction; CELL adhesion
- Publication
Nature Reviews Molecular Cell Biology, 2015, Vol 16, Issue 11, p691
- ISSN
1471-0072
- Publication type
Article
- DOI
10.1038/nrm4068