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- Title
Cell adhesion: The 'ins' and 'outs' of integrin signalling.
- Authors
Wrighton, Katharine H.
- Abstract
The article discusses research being done on the role of binding proteins talin and Gα13 in integrin signalling. It references the study "A directional switch of integrin signalling and a new anti-thrombotic strategy," by B. Shen and colleagues in the 2013 issue of the journal "Nature." It mentions that the researchers found that Gα13 and talin binds β3 in an exclusive but regulated manner and mediates integrin signalling direction.
- Subjects
MOLECULAR structure of carrier proteins; CARRIER protein genetics; INTEGRINS; TALINS (Proteins); THROMBIN; CELL adhesion
- Publication
Nature Reviews Molecular Cell Biology, 2013, Vol 14, Issue 12, p752
- ISSN
1471-0072
- Publication type
Article
- DOI
10.1038/nrm3708