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- Title
The functions and regulation of the PTEN tumour suppressor.
- Authors
Song, Min Sup; Salmena, Leonardo; Pandolfi, Pier Paolo
- Abstract
The importance of the physiological function of phosphatase and tensin homologue (PTEN) is illustrated by its frequent disruption in cancer. By suppressing the phosphoinositide 3-kinase (PI3K)-AKT-mammalian target of rapamycin (mTOR) pathway through its lipid phosphatase activity, PTEN governs a plethora of cellular processes including survival, proliferation, energy metabolism and cellular architecture. Consequently, mechanisms regulating PTEN expression and function, including transcriptional regulation, post-transcriptional regulation by non-coding RNAs, post-translational modifications and protein-protein interactions, are all altered in cancer. The repertoire of PTEN functions has recently been expanded to include phosphatase-independent activities and crucial functions within the nucleus. Our increasing knowledge of PTEN and pathologies in which its function is altered will undoubtedly inform the rational design of novel therapies.
- Subjects
PHOSPHATASES; RAPAMYCIN; HUMAN cytogenetics; PHOSPHOINOSITIDES; CELL proliferation; ENERGY metabolism; HUMAN chromosome abnormalities; PHYSIOLOGY; THERAPEUTICS
- Publication
Nature Reviews Molecular Cell Biology, 2012, Vol 13, Issue 5, p283
- ISSN
1471-0072
- Publication type
Article
- DOI
10.1038/nrm3330