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- Title
Molecular mechanisms underlying the regulation and functional plasticity of FOXP3<sup>+</sup> regulatory T cells.
- Authors
Gao, Y; Lin, F; Su, J; Gao, Z; Li, Y; Yang, J; Deng, Z; Liu, B; Tsun, A; Li, B
- Abstract
CD4+ CD25+ regulatory T (Treg) cells engage in the maintenance of immunological self-tolerance and homeostasis by limiting aberrant or excessive inflammation. The transcription factor forkhead box P3 (FOXP3) is critical for the development and function of Treg cells. The differentiation of the Treg cell lineage is not terminal, as developmental and functional plasticity occur through the sensing of inflammatory signals in the periphery. Here, we review the recent progress in our understanding of the molecular mechanisms underlying the regulation and functional plasticity of CD4+ CD25+ FOXP3+ Treg cells, through the perturbation of FOXP3 and its complex at a transcriptional, translational and post-translational level.
- Subjects
T cells; HOMEOSTASIS; TRANSCRIPTION factors; CELL lines; INFLAMMATION; FORKHEAD transcription factors
- Publication
Genes & Immunity, 2012, Vol 13, Issue 1, p1
- ISSN
1466-4879
- Publication type
Article
- DOI
10.1038/gene.2011.77