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- Title
Introducing a new recruitment approach to sample collection for genetic association studies in opioid dependence
- Authors
Franke, Petra; Wendel, Birgit; Knapp, Michael; Schwab, Sibylle G.; Neef, Daniela; Maier, Wolfgang; Wildenauer, Dieter B.; Hoehe, Margret R.
- Abstract
Objective. – In a modified case–control association study we tested the assumption that two polymorphisms (A118G in exon 1 and IVS2+31 in intron 2) of the human μ-opioid receptor gene (OPRM1) confer susceptibility to opioid dependence.Methods. – In contrast to classical case–control studies both groups, opioid dependent cases and non-opioid dependent controls were recruited from individuals who have had access to drugs including opioids and who had been sentenced for violation of the “Dangerous Drugs Act” in Germany.Results. – For the two allelic variants of OPRM1 under study we did not find evidence for association with opioid dependence.Conclusions. – Despite absence of association we think that this recruitment approach introduced here, is useful since it putatively offers a more adequate matching for case–control association studies of opioid dependent individuals.
- Subjects
OPIOIDS; GENETIC polymorphisms
- Publication
European Psychiatry, 2003, Vol 18, Issue 1, p18
- ISSN
0924-9338
- Publication type
Article
- DOI
10.1016/S0924-9338(02)00005-6