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- Title
Engineering cartilage graft using mesenchymal stem cell laden polyacrylamide-galactoxyloglucan hydrogel for transplantation.
- Authors
Gopalakrishnan Usha, Preethi; Jalajakumari, Sreekutty; Sheela, Unnikrishnan Babukuttan; Mohan, Deepa; Berry, Catherine; Tripathi, Anuj; Thankappan Nair, Sreelekha T
- Abstract
Hydrogels are reported to have various biomedical field applications, and many reports also suggest that soft gels promote stem cell differentiation. Chondrogenic differentiation of mesenchymal stem cells (MSC) is significant in articular cartilage repair. This study focuses on polysaccharide-based hydrogels which enhance chondrocyte lineage differentiation of MSC when grown in the hydrogels. This study implies that the prepared hydrogels promote specific lineage without any external chemical induction factors. The techniques, including immunofluorescence and functional assays to assess the differentiation and in vivo implantation, were employed. All observations paved the way towards confirmation that the galactoxyloglucan-based hydrogel is an attractive candidate for supporting stem cell growth and cartilaginous differentiation.
- Subjects
MESENCHYMAL stem cells; MESENCHYMAL stem cell differentiation; CARTILAGE regeneration; CARTILAGE; ARTICULAR cartilage
- Publication
Journal of Biomaterials Applications, 2021, Vol 36, Issue 3, p541
- ISSN
0885-3282
- Publication type
Article
- DOI
10.1177/08853282211019521