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- Title
4-Hydroxyderricin Promotes Apoptosis and Cell Cycle Arrest through Regulating PI3K/AKT/mTOR Pathway in Hepatocellular Cells.
- Authors
Gao, Xiang; Jiang, Yuhuan; Xu, Qi; Liu, Feng; Pang, Xuening; Wang, Mingji; Li, Qun; Li, Zichao
- Abstract
4-hydroxyderricin (4-HD), as a natural flavonoid compound derived from Angelica keiskei, has largely unknown inhibition and mechanisms on liver cancer. Herein, we investigated the inhibitory effects of 4-HD on hepatocellular carcinoma (HCC) cells and clarified the potential mechanisms by exploring apoptosis and cell cycle arrest mediated via the PI3K/AKT/mTOR signaling pathway. Our results show that 4-HD treatment dramatically decreased the survival rate and activities of HepG2 and Huh7 cells. The protein expressions of apoptosis-related genes significantly increased, while those related to the cell cycle were decreased by 4-HD. 4-HD also down-regulated PI3K, p-PI3K, p-AKT, and p-mTOR protein expression. Moreover, PI3K inhibitor (LY294002) enhanced the promoting effect of 4-HD on apoptosis and cell cycle arrest in HCC cells. Consequently, we demonstrate that 4-HD can suppress the proliferation of HCC cells by promoting the PI3K/AKT/mTOR signaling pathway mediated apoptosis and cell cycle arrest.
- Subjects
CELL cycle; CELLULAR signal transduction; SURVIVAL rate; CELL proliferation; APOPTOSIS; LIVER cancer
- Publication
Foods, 2021, Vol 10, Issue 9, p2036
- ISSN
2304-8158
- Publication type
Article
- DOI
10.3390/foods10092036