We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Establishing Antimicrobial Susceptibility Testing Methods and Clinical Breakpoints for Inhaled Antibiotic Therapy.
- Authors
Ekkelenkamp, Miquel B; Díez-Aguilar, María; Tunney, Michael M; Elborn, J Stuart; Fluit, Ad C; Cantón, Rafael
- Abstract
Inhaled antibiotics are a common and valuable therapy for patients suffering from chronic lung infection, with this particularly well demonstrated for patients with cystic fibrosis. However, in vitro tests to predict patient response to inhaled antibiotic therapy are currently lacking. There are indications that antimicrobial susceptibility testing (AST) may have a role in guidance of therapy, but which tests would correlate best still needs to be researched in clinical studies or animal models. Applying the principles of European Committee on Antimicrobial Susceptibility Testing methodology, the analysis of relevant and reliable data correlating different AST tests to patients' outcomes may yield clinical breakpoints for susceptibility, but these data are currently unavailable. At present, we believe that it is unlikely that standard determination of minimum inhibitory concentration will prove the best predictor.
- Publication
Open Forum Infectious Diseases, 2022, Vol 9, Issue 4, p1
- ISSN
2328-8957
- Publication type
Article
- DOI
10.1093/ofid/ofac082