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- Title
Sustained Response and Rationale of Programmed Cell Death-1-Targeting for Progressive Multifocal Leukoencephalopathy.
- Authors
Audemard-Verger, Alexandra; Gasnault, Jacques; Faisant, Maxime; Besse, Marie-Catherine; Martin-Silva, Nicolas; Berra, Mado; Fournier, Luc; Boutemy, Jonathan; Maigne, Gwenola; Boysson, Hubert De; Ruet, Alexis; Vabret, Astrid; Chapon, Françoise; Martin-Blondel, Guillaume; Aouba, Achille
- Abstract
In this study, we report a complete (clinical, radiological, and virological) sustained (1 year) response after nivolumab salvage therapy in a progressive multifocal leukoencephalopathy patient. Analyses of the cells infiltrate in a pretreatment brain biopsy suggest that parenchymal programmed cell death-L1+ macrophages could be the T-cells partnership in immune exhaustion and virus escape.
- Subjects
PROGRESSIVE multifocal leukoencephalopathy; JOHN Cunningham virus; CELL analysis; SALVAGE therapy
- Publication
Open Forum Infectious Diseases, 2019, Vol 6, Issue 10, pN.PAG
- ISSN
2328-8957
- Publication type
Article
- DOI
10.1093/ofid/ofz374