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- Title
Isocyanates may contribute to allergic contact dermatitis from diabetes devices and wound dressings.
- Authors
Dendooven, Ella; Foubert, Kenn; Naessens, Tania; Pieters, Luc; Lambert, Julien; Aerts, Olivier
- Abstract
Background: Isocyanates are well‐known occupational allergens, but can also be present in medical devices. Objectives: To highlight that contact sensitization to isocyanates might contribute to allergic contact dermatitis (ACD) from polyurethane (PU)‐containing diabetes devices and wound dressings. Patients and Methods: Nineteen patients with suspected ACD from diabetes devices and/or wound dressings were patch tested to an isocyanate series. Four wound dressings, six diabetes devices and four monomeric isocyanate patch test preparations were analysed with gas chromatography – mass spectrometry. Results: Eight patients reacted to isocyanates and corresponding amines: 3 to isophorone diisocyanate (IPDI), 4 to 4,4′‐diaminodiphenylmethane (MDA), 4 to 2,4‐toluene diisocyanate (TDI) and 1 to polymeric methylene diphenyl diisocyanate (PMDI). Three of four wound dressings contained isocyanates (methylene diphenyl diisocyanate [MDI], TDI and/or IPDI), whereas five of six diabetes devices contained 4,4′‐MDI, and one of them also IPDI. None of the medical devices contained 1,6‐hexamethylene diisocyanate. Contrary to IPDI, and especially MDI, only the concentration of the TDI patch test preparation corresponded approximately (80%) to its label. Conclusion: Patch tests with isocyanates may be worth‐while in patients with suspected ACD from PU‐containing medical devices. Besides MDA, and PMDI, also TDI might potentially be a marker for MDI‐sensitization.
- Subjects
CONTACT dermatitis; METHYLENE diphenyl diisocyanate; ISOCYANATES; DIABETES; MEDICAL equipment; HYDROCOLLOID surgical dressings
- Publication
Contact Dermatitis (01051873), 2022, Vol 87, Issue 5, p414
- ISSN
0105-1873
- Publication type
Article
- DOI
10.1111/cod.14187