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- Title
External globus pallidus stimulation modulates brain connectivity in Huntington's disease.
- Authors
Ligot, Noémie; Krystkowiak, Pierre; Simonin, Clémence; Goldman, Serge; Peigneux, Philippe; Van Naemen, John; Monclus, Michel; Lacroix, Simon Frédéric; Devos, David; Dujardin, Kathy; Delmaire, Christine; Bardinet, Eric; Delval, Arnaud; Delliaux, Marie; Defebvre, Luc; Yelnik, Jerome; Blond, Serge; Destée, Alain; De Tiège, Xavier
- Abstract
Positron emission tomography with O-15-labeled water was used to study at rest the neurophysiological effects of bilateral external globus pallidus (GPe) deep brain stimulation in patients with Huntington's disease (HD). Five patients were compared with a control group in the on and off states of the stimulator. External globus pallidus stimulation decreased neuronal activity and modulated cerebral connectivity within the basal ganglia-thalamocortical circuitry, the sensorimotor, and the default-mode networks. These data indicate that GPe stimulation modulates functional integration in HD patients in accordance with the basal ganglia-thalamocortical circuit model.
- Subjects
GLOBUS pallidus; HUNTINGTON disease; POSITRON emission tomography; NEUROPHYSIOLOGY; BRAIN stimulation; BASAL ganglia; NEURAL circuitry; SENSORIMOTOR cortex
- Publication
Journal of Cerebral Blood Flow & Metabolism, 2011, Vol 31, Issue 1, p41
- ISSN
0271-678X
- Publication type
Article
- DOI
10.1038/jcbfm.2010.186