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- Title
Dengue Virus Entry and Replication Does Not Lead to Productive Infection in Platelets.
- Authors
Kar, Meenakshi; Singla, Mohit; Chandele, Anmol; Kabra, Sushil K.; Lodha, Rakesh; Medigeshi, Guruprasad R.
- Abstract
Thrombocytopenia is a characteristic feature during the acute phase of dengue infection and has been found to associate with vascular leakage in severe dengue. Although dengue antigens have been observed in platelets, there is no strong evidence to suggest a direct infection of platelets by dengue virus as a contributing factor for thrombocytopenia. We show that dengue virus can enter platelets but replicate viral ribonucleic acid to a minimal extent and, therefore, cannot produce infectious virus. Dengue antigen was undetectable in platelets isolated from dengue patients; however, we observed an increase in CD14+CD16+ monocyte-platelet complexes, suggesting a mechanism for platelet clearance.
- Subjects
DENGUE viruses; VIRAL replication; BLOOD platelet disorders
- Publication
Open Forum Infectious Diseases, 2017, Vol 4, Issue 2, p1
- ISSN
2328-8957
- Publication type
Article
- DOI
10.1093/ofid/ofx051