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- Title
G-CSF administration is neuroprotective following transient cerebral ischemia even in the absence of a functional NOS-2 gene.
- Authors
Gibson, Claire L; Bath, Philip M. W.; Murphy, Sean P.
- Abstract
Granulocyte colony-stimulating factor (G-CSF) is a candidate neuroprotective factor following cerebral ischemia. To determine whether G-CSF acts partly through the inhibition of nitric oxide synthase (NOS)-2 expression, we administered G-CSF to male NOS-2−/− mice after cerebral ischemia. Although male NOS-2−/− mice exhibit resistance to the gross effects of cerebral ischemia, they display neuronal loss and skilled motor deficits following cerebral ischemia. Administration of G-CSF during reperfusion reduced motor deficit and neuronal loss. Thus, G-CSF is still effective in NOS-2 gene-deficient mice, suggesting that part of the mechanism of action is independent of NOS-2.
- Subjects
NEUROPROTECTIVE agents; ISCHEMIA; NITRIC oxide; MOVEMENT disorders; CEREBROSPINAL fluid
- Publication
Journal of Cerebral Blood Flow & Metabolism, 2010, Vol 30, Issue 4, p739
- ISSN
0271-678X
- Publication type
Article
- DOI
10.1038/jcbfm.2010.12